Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts
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چکیده
منابع مشابه
Impairment of gingival fibroblast adherence by IL-6/sIL-6R.
Interleukin-6 (IL-6) binds to human gingival fibroblasts (HGF) in the presence of a soluble form of IL-6 receptor (sIL-6R). We investigated the effects of IL-6 on the functions of HGF in the presence of sIL-6R. HGF changed their morphology from spindle-shaped to round, and detached from the culture dish by stimulation with IL-6/sIL-6R. In this condition, a signal transducer gp130 and a transcri...
متن کاملZoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts
Bisphosphonates (BPs) are analogues of pyrophosphate that are known to prevent bone resorption by inhibiting osteoclast activity. Nitrogen-containing BPs, such as zoledronic acid (ZA), are widely used in the treatment of osteoporosis and bone metastasis. However, despite having benefits, ZA has been reported to induce BP-related osteonecrosis of the jaw (BRONJ) in cancer patients. The molecular...
متن کاملMacrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts
OBJECTIVE Macrolide antibiotics are reported to modulate the production of cytokines in various type of cells. We examined the effect of macrolide antibiotics on inflammatory cytokines (IL-6 and IL-8) and chemical mediator (PGE(2)) and also matrix metalloproteinases (MMPs) productions by human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS). METHODS The effect of macrolide a...
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OBJECTIVE—In periodontitis, matrix metalloproteinase 3 (MMP-3, stromelysin 1) is present at increased levels in active disease sites compared to inactive or healthy sites, and the levels are correlated with clinical parameters and associated with progression of the disease. Interleukin 4 (IL-4) has been shown in other systems to suppress interleukin-1 (IL-1) induced expression of MMP-3, but thi...
متن کاملCytokine secretion in cultured human gingival fibroblasts in response to LPS or gingival overgrowth-inducing drugs
Human normal, periodontitis and overgrown gingival fibroblasts were assayed concerning proinflammatory cytokines secreting ability. Stimulating effect of gingival overgrowth-inducing drugs such as phenytoin, nifedipine or cyclosporine A and LPS on the secretion ability of each fibroblast specimen was also estimated. The supernatant of cultured medium was assayed cytokines by ELISA techniques. I...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2018
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2018.e00979